Michael S Wolin Selected Research

NADP (NADPH)

10/2019	Metabolism and Redox in Pulmonary Vascular Physiology and Pathophysiology.
1/2016	20-HETE-induced mitochondrial superoxide production and inflammatory phenotype in vascular smooth muscle is prevented by glucose-6-phosphate dehydrogenase inhibition.
2/2014	Dehydroepiandrosterone promotes pulmonary artery relaxation by NADPH oxidation-elicited subunit dimerization of protein kinase G 1α.
8/2013	Roles for cytosolic NADPH redox in regulating pulmonary artery relaxation by thiol oxidation-elicited subunit dimerization of protein kinase G1α.
12/2011	Roles for redox mechanisms controlling protein kinase G in pulmonary and coronary artery responses to hypoxia.
12/2010	Redox regulation of guanylate cyclase and protein kinase G in vascular responses to hypoxia.
8/2010	Redox regulation of responses to hypoxia and NO-cGMP signaling in pulmonary vascular pathophysiology.
6/2010	Activation of glucose-6-phosphate dehydrogenase promotes acute hypoxic pulmonary artery contraction.
3/2010	Oxidant-redox regulation of pulmonary vascular responses to hypoxia and nitric oxide-cGMP signaling.
7/2009	Superoxide production by NAD(P)H oxidase and mitochondria is increased in genetically obese and hyperglycemic rat heart and aorta before the development of cardiac dysfunction. The role of glucose-6-phosphate dehydrogenase-derived NADPH.

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Michael S Wolin Research Topics

Disease

32	Hypoxia (Hypoxemia) 01/2020 - 08/2003
14	Pulmonary Hypertension 01/2020 - 06/2008
7	Hypertension (High Blood Pressure) 01/2017 - 09/2003
5	Inflammation (Inflammations) 01/2021 - 01/2007
5	Vascular Remodeling 10/2019 - 07/2006
5	Heart Failure 10/2011 - 02/2003
4	Vascular Diseases (Vascular Disease) 05/2011 - 03/2009
3	Hypertrophy 10/2011 - 05/2008
2	Pulmonary Arterial Hypertension 01/2021 - 01/2017
2	Cardiotoxicity 07/2014 - 02/2003
2	Heart Diseases (Heart Disease) 10/2011 - 02/2010
2	Fibrosis (Cirrhosis) 10/2011 - 05/2008
2	Hyperglycemia 07/2009 - 11/2007
2	Ischemia 04/2008 - 10/2003
2	Diabetes Mellitus 11/2007 - 03/2007
2	Hyperhomocysteinemia 03/2007 - 03/2003
1	Hydrocephalus (Hydrocephaly) 01/2021
1	Hemorrhage 01/2021
1	Mitochondrial Diseases (Mitochondrial Disease) 10/2019

Drug/Important Bio-Agent (IBA)

21	Superoxides (Superoxide)IBA 11/2019 - 03/2003
17	NADP (NADPH)IBA 10/2019 - 08/2005
11	PeroxidesIBA 08/2014 - 12/2003
10	Reactive Oxygen Species (Oxygen Radicals)IBA 11/2019 - 06/2006
9	NADPH Oxidases (NAD(P)H oxidase)IBA 09/2010 - 03/2003
9	Oxidoreductases (Dehydrogenase)IBA 08/2010 - 01/2005
7	Oxygen (Dioxygen)IBA 10/2019 - 08/2005
7	Oxidants (Oxidizing Agents)IBA 04/2015 - 05/2005
6	Glucose (Dextrose)FDA LinkGeneric 10/2019 - 10/2003
6	NAD (NADH)IBA 10/2019 - 01/2005
6	Nitric Oxide Synthase (NO Synthase)IBA 07/2014 - 03/2007
6	Nitric Oxide (Nitrogen Monoxide)FDA Link 09/2010 - 02/2003
5	Proteins (Proteins, Gene)FDA Link 01/2021 - 08/2006
5	Cyclic GMP-Dependent Protein Kinases (Protein Kinase G)IBA 10/2019 - 12/2010
5	Glucosephosphate Dehydrogenase (Glucose 6 Phosphate Dehydrogenase)IBA 10/2019 - 08/2005
5	CalciumIBA 01/2017 - 11/2004
5	Heme (Haem)IBA 04/2015 - 03/2010
5	Soluble Guanylyl CyclaseIBA 08/2014 - 08/2003
5	Sulfhydryl Compounds (Thiols)IBA 08/2013 - 06/2006
5	Adenosine Triphosphate (ATP)IBA 06/2010 - 10/2003
4	Small Interfering RNA (siRNA)IBA 11/2019 - 06/2010
4	Lactic Acid (Lactate)FDA LinkGeneric 10/2019 - 10/2003
4	AcidsIBA 01/2017 - 11/2004
4	Superoxide DismutaseIBA 04/2015 - 03/2003
4	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 08/2014 - 03/2009
4	Vasodilator Agents (Vasodilators)IBA 02/2014 - 08/2005
3	IronIBA 10/2019 - 04/2015
3	ProstaglandinsIBA 10/2019 - 11/2004
3	Guanylate Cyclase (Guanylyl Cyclase)IBA 01/2017 - 08/2010
3	vasodilator-stimulated phosphoproteinIBA 08/2014 - 12/2011
3	6-Aminonicotinamide (6 Aminonicotinamide)IBA 08/2013 - 06/2006
3	Serotonin (5 Hydroxytryptamine)IBA 10/2010 - 08/2003
3	Pyruvic Acid (Pyruvate)IBA 06/2010 - 06/2006
3	SmokeIBA 01/2009 - 01/2007
3	NF-kappa B (NF-kB)IBA 06/2008 - 07/2006
2	Prostaglandin H2 (PGH(2))IBA 01/2017 - 11/2007
2	Epoxide HydrolasesIBA 01/2017 - 12/2015
2	10,10'-dimethyl-9,9'-biacridinium (Lucigenin)IBA 04/2015 - 08/2006
2	Aminolevulinic Acid (Levulan)FDA Link 04/2015 - 08/2014
2	src-Family KinasesIBA 04/2015 - 12/2009
2	Doxorubicin (Adriamycin)FDA LinkGeneric 07/2014 - 02/2003
2	AndrosteroneIBA 08/2013 - 06/2006
2	Dithiothreitol (Cleland's Reagent)IBA 12/2011 - 06/2006
2	sapropterin (tetrahydrobiopterin)FDA Link 10/2011 - 05/2008
2	Indomethacin (Indometacin)FDA LinkGeneric 09/2010 - 11/2004
2	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA 09/2010 - 11/2004
2	tempolIBA 09/2010 - 05/2008
2	Adenosine Diphosphate (ADP)IBA 06/2010 - 04/2008
2	ebselenIBA 06/2010 - 12/2003
2	15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic AcidIBA 12/2009 - 06/2006
2	RotenoneIBA 12/2009 - 09/2008
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 09/2009 - 03/2003
2	AntioxidantsIBA 09/2009 - 05/2008
2	CytokinesIBA 09/2009 - 01/2009
2	ResveratrolIBA 09/2009 - 06/2008
2	MonocrotalineIBA 09/2009 - 06/2008
2	Protein Kinase CIBA 04/2009 - 06/2006
2	Uric Acid (Urate)IBA 04/2008 - 10/2003
2	Arginine (L-Arginine)FDA Link 03/2007 - 10/2003
2	cyclopiazonic acidIBA 06/2006 - 11/2004
2	Potassium Channels (Potassium Channel)IBA 08/2005 - 11/2004
2	Peroxynitrous Acid (Peroxynitrite)IBA 10/2003 - 02/2003
1	Aquaporins (Water Channels)IBA 01/2021
1	Protein Isoforms (Isoforms)IBA 01/2021
1	Glycerol (Glycerine)FDA LinkGeneric 01/2021
1	Interleukin-10 (Interleukin 10)IBA 01/2021
1	Type II Bone Morphogenetic Protein Receptors (Bone Morphogenetic Protein Receptor Type II)IBA 01/2021
1	Adrenergic Receptors (Adrenergic Receptor)IBA 01/2020
1	MitoTEMPOIBA 11/2019
1	5- (6'- triphenylphosphoniumhexyl)- 5,6- dihydro- 6- phenyl- 3,8- phenanthridinediammineIBA 11/2019
1	Cartilage Oligomeric Matrix ProteinIBA 11/2019
1	CalponinsIBA 11/2019
1	TEMPOIBA 11/2019
1	Bone Morphogenetic Proteins (Bone Morphogenetic Protein)IBA 11/2019
1	Cytochrome P-450 CYP2C9IBA 10/2019
1	superoxide dismutase 2IBA 10/2019
1	4- (4- (3- (4- trifluoromethoxy- phenyl)ureido)cyclohexyloxy)benzoic acidIBA 01/2017
1	11,12-epoxy-5,8,14-eicosatrienoic acidIBA 01/2017
1	14,15-epoxy-5,8,11-eicosatrienoic acidIBA 01/2017
1	14,15-eicosa-5-enoic acidIBA 01/2017

Therapy/Procedure

1	Bone Marrow Transplantation (Transplantation, Bone Marrow) 01/2020